Effectiveness of Iron Supplementation on Platelets Count and the Reduction of Lactic Acid Formation in Female Athletes

Authors

  • Tehreem Gul The University of Haripur, Haripur.
  • Syed Zia Ul Islam The University of Haripur, Haripur.
  • Ramisha Riaz The university of Haripur, Haripur.

Keywords:

Iron Supplementation, Lactic Acid, Platelet Count, Female Athletes

Abstract

Fatigue is a universal symptom not only associated with most acute and chronic illnesses but also with normal, healthy athletes who have low energy due to a poor diet. Fatigue is caused by the high production of lactic acid and low platelet count in athletes’ blood. This study aimed to assess the effectiveness of iron supplementation on iron concentration and platelet count, leading to a reduction in both lactic acid formation and deposition in female athletes. The study was conducted on 18 female athletes aged 18 to 25 years who voluntarily participated in the study. An experimental research design was randomly and equally employed, with three groups, i.e., control group (C.G), experimental Group (GA), and experimental Group (GB). The experimental groups received iron supplementation with different dosages and time-dependent, i.e., two doses (FeSO4: 320±5mg) twice a week for 4 weeks (Group A) and the same dose once a week for 8 weeks (Group B), while the control group followed their usual routine schedule. This study was further divided into different intervals, i.e., pre-test, intermediate, and post-test, respectively. Blood sampling was done at the above-mentioned intervals. The blood samples from the clinical lab were analyzed for hemoglobin, iron concentration, platelet count, and lactic acid burden. The results were analyzed using paired sample t-tests, ANOVA test, mean, and standard deviation measurements by using Prism GraphPad 5 software. The data analysis provided insights into the effectiveness of iron supplementation in improving iron levels (mg/dL), platelet counts (x10^9/L), and reducing lactic acid formation (mg/dL). This study highlights the potential benefits of iron supplementation in both groups, but more significantly in short-duration and multiple dose in female athletes. These findings contribute to the understanding of how iron supplementation can positively affect platelet count and reduce lactic acid burden, potentially leading to improved athletic performance and fatigue.

Author Biographies

Tehreem Gul, The University of Haripur, Haripur.

M.Phil. Scholar, Department of Sports Science and Physical Education, The University of Haripur, Haripur, Pakistan.

Syed Zia Ul Islam, The University of Haripur, Haripur.

Associate Professor, Department of Sports Science and Physical Education, The University of Haripur, Haripur, Pakistan.

Ramisha Riaz, The university of Haripur, Haripur.

M.Phil. Scholar, Department of Sports Science and Physical Education, The University of Haripur, Haripur, Pakistan.

References

Alamin, A. A. (2021). The role of red blood cells in hemostasis. Seminars in Thrombosis and Hemostasis. https://doi.org/10.1055/s-0041-1722944

Brissot, E., Troadec, M. B., Loréal, O., & Brissot, P. (2021). Iron and platelets: A subtle, underrecognized relationship. American Journal of Hematology, 96(8), 1008–1016. https://doi.org/10.1002/ajh.26230

Camaschella, C. (2019). Iron deficiency. Blood, 133(1), 30–39. https://doi.org/10.1182/blood-2018-05-815944

Desbrow, B. (2021). Youth athlete development and nutrition. Sports Medicine, 51(Suppl 1), 3–12. https://doi.org/10.1007/s40279-021-01485-y

Hall, M. M., Rajasekaran, S., Thomsen, T. W., & Peterson, A. R. (2016). Lactate: Friend or foe? PM&R, 8(3 Suppl), S8–S15. https://doi.org/10.1016/j.pmrj.2015.10.018

Halson, S. (2014). Monitorización de la carga de formación para conocer fatiga en los atletas. Sports Medicine, 44(Suppl 2), 139–147. https://doi.org/10.1007/s40279-014-0253-z

Holtzman, B., & Ackerman, K. E. (2021). Recommendations and nutritional considerations for female athletes: Health and performance. Sports Medicine, 51(Suppl 1), 43–57. https://doi.org/10.1007/s40279-021-01487-w

Indraccolo, U., Gentile, G., Pomili, G., Luzi, G., & Villani, C. (2005). Thiamine deficiency and beriberi features in a patient with hyperemesis gravidarum. Nutrition, 21(9), 967–968. https://doi.org/10.1016/j.nut.2005.02.004

Klingshirn, L. A., Pate, R. R., Bourque, S. P., Davis, J. M., & Sargent, R. G. (1992). Effect of iron supplementation on endurance capacity in iron-depleted female runners. Medicine & Science in Sports & Exercise, 24(7), 819–824. https://doi.org/10.1249/00005768-199207000-00005

Kuwabara, A. M., Tenforde, A. S., Finnoff, J. T., & Fredericson, M. (2022). Iron deficiency in athletes: A narrative review. PM&R, 14(5), 620–642. https://doi.org/10.1002/pmrj.12786

Lamke, A. M. (2021). Use of supplemental iron for the enhancement of physical performance in competitive non-anemic female athletes [Master’s thesis, University not specified].

Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., & Geyer, H. (2018). IOC consensus statement: Dietary supplements and the high-performance athlete. International Journal of Sport Nutrition and Exercise Metabolism, 28(2), 104–125. https://doi.org/10.1123/ijsnem.2018-0020

McCormick, R., Sim, M., Dawson, B., & Peeling, P. (2020). Refining treatment strategies for iron-deficient athletes. Sports Medicine, 50, 2111–2123. https://doi.org/10.1007/s40279-020-01328-0

Ni, S., Yuan, Y., Kuang, Y., & Li, X. (2022). Iron metabolism and immune regulation. Frontiers in Immunology, 13, 816282. https://doi.org/10.3389/fimmu.2022.816282

Pantopoulos, K. (2024). Oral iron supplementation: New formulations, old questions. Haematologica, 109(9), 2790–2793. https://doi.org/10.3324/haematol.2023.283138

Pedlar, C. R., Brugnara, C., Bruinvels, G., & Burden, R. (2018). Iron balance and iron supplementation for the female athlete: A practical approach. European Journal of Sport Science, 18(2), 295–305. https://doi.org/10.1080/17461391.2017.1416176

Penna, E. M., Wanner, S. P., Campos, B. T., Quinan, G. R., Mendes, T. T., Smith, M. R., & Prado, L. S. (2018). Mental fatigue impairs physical performance in young swimmers. Pediatric Exercise Science, 30(2), 208–215. https://doi.org/10.1123/pes.2017-0123

Roweth, H. G., & Battinelli, E. M. (2023). Platelet and (lymph)angiogenesis. Cold Spring Harbor Perspectives in Medicine, 13(1), a041174. https://doi.org/10.1101/cshperspect.a041174

Rusdiawan, A., Sholikhah, A. M. A., & Prihatiningsih, S. (2020). The changes in pH levels, blood lactic acid, and fatigue index to anaerobic exercise on athletes after NaHCO3. Malaysian Journal of Medical and Health Sciences, 16(16), 50–56.

Seheult, J., Fitzpatrick, G., & Boran, G. (2017). Lactic acidosis: An update. Clinical Chemistry and Laboratory Medicine, 55(3), 322–333. https://doi.org/10.1515/cclm-2016-0283

Shaw, K. A. (2023). Biofortification of plant-based food products and applications to the athlete. [Publication or university info not provided].

Stoffel, N. U., von Siebenthal, H. K., Moretti, D., & Zimmermann, M. B. (2020). Oral iron supplementation in iron-deficient women: How much and how often? Molecular Aspects of Medicine, 75, 100865. https://doi.org/10.1016/j.mam.2020.100865

Westerterp, K. R. (2009). Assessment of physical activity: A critical appraisal. European Journal of Applied Physiology, 105(6), 823–828. https://doi.org/10.1007/s00421-009-1000-2

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Published

2024-12-30

How to Cite

Gul, T., Islam, S. Z. U., & Riaz, R. (2024). Effectiveness of Iron Supplementation on Platelets Count and the Reduction of Lactic Acid Formation in Female Athletes. Sports Sciences and Physical Education Review, 3(2), I - XII. Retrieved from https://saturnpublications.com/index.php/ssper/article/view/46